Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorderResearch in context

Summary: Background: Bipolar disorder (BD) is a multifactorial psychiatric illness affecting ∼1% of the global adult population. Lithium (Li), is the most effective mood stabilizer for BD but works only for a subset of patients and its mechanism of action remains largely elusive. Methods: In the pr...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Anouar Khayachi, Malak Abuzgaya, Yumin Liu, Chuan Jiao, Kurt Dejgaard, Lenka Schorova, Anusha Kamesh, Qin He, Yuting Cousineau, Alessia Pietrantonio, Nargess Farhangdoost, Charles-Etienne Castonguay, Boris Chaumette, Martin Alda, Guy A. Rouleau, Austen J. Milnerwood
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Bipolar disorder Lithium responsiveness iPSC-derived neurons Phosphoproteomics Akt and AMPK pathways
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396424001968