Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes

Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to drug detoxification, cell metabolism, and homeostasis. CYP450s belonging to CYP families 1–3 are responsible for nearly 80% of oxidative metabolism and complete elimination of approximately 50% of all common clinica...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xiaokang Wang, Jiaoyu Rao, Zhiyi Tan, Tianrong Xun, Jingqian Zhao, Xixiao Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	cytochrome P450 inflammatory signaling drug metabolism hepatocytes clinical application
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1043836/full