Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum.

The control of instrumental actions engages distinct behavioral strategies whose contributions are regulated with experience. Instrumental performance, which depends on the causal relationship between actions and their outcomes (A-O), relies on flexible, goal-directed control of behavior. Actions ca...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Vincent Paget-Blanc, Anna Cavaccini, Alessandra Longaretti, Luca Nava, Massimo Trusel, Anna Rocchi, Maria Pennuto, Elena Marcello, Fabrizio Gardoni, Barbara Greco, Raffaella Tonini
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-07-01
Online Access:	https://doi.org/10.1371/journal.pbio.3003288