Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

Abstract The genetic factors influencing human longevity have long been a subject of curiosity, linking ancient historical records with modern genomic research. This study seeks to identify key genetic contributors to lifespan by integrating genome-wide association studies (GWAS) with functional ann...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Scientific Reports
المؤلفون الرئيسيون:	Rahmat Dani Satria, Usi Sukorini, Mohammad Hendra Setia Lesmana, Lalu Muhammad Irham, Wirawan Adikusuma, Hegaria Rahmawati, Nur Imma Fatimah Harahap, Pranindya Rinastiti, Donytra Arby Wardhana, Osman Sianipar, Gisca Ajeng Widya Ninggar, Zaenal Muttaqien Sofro, Nova Yuli Prasetyo Budi, Josephine Diony Nanda, Faizul Hasan, Tri Budi W. Rahardjo, Chiou-Feng Lin
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2025-07-01
الموضوعات:	Longevity APOE SNP Bioinformatics GWAS
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-025-02848-5