Recellularization of decellularized vascular grafts via aligned seeding of endothelial cells derived from human iPS cells

Abstract The development of decellularized vascular tissues for tissue engineering and vascular implants presents a promising approach to creating functional blood vessels. However, effective endothelialization with human endothelial cells remains challenging. This study examined the endothelializat...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mako Kobayashi, Kozue Murata, Masaya Yamamoto, Yoshihide Hashimoto, Tsuyoshi Kimura, Hidetoshi Masumoto, Akio Kishida
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Subjects:	Human induced pluripotent stem — derived vascular endothelial cells (hiPSC-ECs) Decellularized vascular tissue Surface topography Cell adhesion and alignment
Online Access:	https://doi.org/10.1038/s41598-025-07458-9