Tuning TCR complex recruitment to the T cell antigen coupler (TAC) enhances TAC-T cell function

Abstract The T cell antigen coupler (TAC) receptor is a novel synthetic receptor designed to maximize the therapeutic potential of T cells in the absence of tonic signaling or receptor-related toxicities. Prior studies indicated that TACs provide safe and long-lasting anti-tumor immunity in multiple...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Trevor M. Morey, Tania Benatar, Stacey X. Xu, Ling Wang, Philbert Ip, Thanyashanthi Nitya-Nootan, Gargi Thakor, Andreas G. Bader, Christopher W. Helsen, Walid A. Houry
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	T cell therapy T cell receptor (TCR) T cell antigen coupler (TAC) UCHT1 Cancer Binding affinity
Online Access:	https://doi.org/10.1038/s41598-025-87944-2