The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis

Osteoarthritis (OA) is a degenerative or posttraumatic condition of the joints. In OA chondrocytes, Nrf2 functions as a stress response regulator with antioxidant and anti-inflammatory effects. This study aims to investigate the role of Nrf2 and its downstream pathway in the development of osteoarth...

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Bibliographic Details

Published in:	Acta Biochimica et Biophysica Sinica
Main Authors:	Li Wenzhao, Tao Cheng, Mao Minzhi, Zhu Kewei
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2023-05-01
Subjects:	osteoarthritis (OA) cartilage chondrocyte extracellular matrix (ECM) Nrf2 HMGB1
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2023078