An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages

Abstract The local inflammatory microenvironment, insufficient vascularization, and inadequate bone repair materials are the three key factors that constrain the repair of bone defects. Here, we synthesized a composite nanoparticle, TPQ (TCP-PDA-QK), with a core‒shell structure. The core consists of...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Huaiyuan Zhang, Yu Wang, Wenyu Qiao, Xueneng Hu, Huifen Qiang, Kuo Xia, Longhai Du, Luling Yang, Yi Bao, Jie Gao, Tinglin Zhang, Zuochong Yu
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Inflammatory microenvironment Bone defects Core‒shell structure M2 macrophage polarization Vascularization Bone regeneration
Online Access:	https://doi.org/10.1186/s12951-025-03358-2