Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity

It has been estimated that 10% of acute liver failure is due to “idiosyncratic hepatotoxicity”. The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were inc...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Jinchun Sun, Svetoslav Slavov, Laura K. Schnackenberg, Yosuke Ando, James Greenhaw, Xi Yang, William Salminen, Donna L. Mendrick, Richard Beger
Format:	Article
Language:	English
Published:	Elsevier 2014-07-01
Subjects:	Metabolomics Biomarker panel Acute hepatotoxicity Idiosyncratic hepatotoxicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037014000154