Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models

Immune checkpoint inhibitors have been found to be effective in metastatic MSI-high colorectal cancers (CRC), however, have no efficacy in microsatellite stable (MSS) cancers, which comprise the majority of mCRC cases. Cabozantinib is a small molecule multi-tyrosine kinase inhibitor that is FDA appr...

Full description

Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Julie Lang, Alexis D. Leal, Juan A. Marín-Jiménez, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Matthew S. Lewis, Anna Capasso, Stacey M. Bagby, Bethlehem W. Yacob, Morgan MacBeth, Brian M. Freed, S. Gail Eckhardt, Kimberly Jordan, Patrick J. Blatchford, Roberta Pelanda, Christopher H. Lieu, Wells A. Messersmith, Todd M. Pitts
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	colorectal cancer immunotherapy tumor immunology tumor microenvironment humanized mouse model immune checkpoint blockade
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.877635/full