Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model

Abstract Background Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage arthritis, the nature of lymphatic muscle cells (L...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	H. Mark Kenney, Chia-Lung Wu, Alayna E. Loiselle, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Format:	Article
Language:	English
Published:	BMC 2022-03-01
Subjects:	Inflammation Arthritis Lymphatics Vasculature Smooth Muscle Cells Fibroblasts
Online Access:	https://doi.org/10.1186/s13075-022-02730-z