Role of metal ions in the cognitive decline of Down syndrome

Down syndrome (DS), caused by trisomy of whole or part of chromosome 21 is the most common mental impairment. All Down syndrome (DS) individuals suffer from cognitive decline and develop Alzheimer’s disease (AD) by the age of forty. The appearance of enlarged early endosomes, followed by Amyloid β p...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Nakisa eMalakooti, Melanie ePritchard, Paul eAdlard, David eFinkelstein
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-06-01
Subjects:	Alzheimer Disease Calcium Copper Down Syndrome Homeostasis Iron
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00136/full