The Story behind the Science: The discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein

ABSTRACT In this article, we reconstruct the history of the science that led to the discovery of CagA, the protein that causes gastric cancer, where teams in the United States and Italy made independent observations that ultimately merged. We also honor the memory of Antonello Covacci, who played an...

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Bibliographic Details

Published in:	mBio
Main Authors:	Rino Rappuoli, Fabio Bagnoli, Martin J. Blaser
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	CagA Helicobacter pylori gastric cancer tumorigenic bacterial protein
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03641-24