Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates

BackgroundAntibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design stud...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leitao Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	antibody-drug conjugate pharmacokinetic/pharmacodynamic targeted antibodies toxins pharmacokinetics pharmacodynamics
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1459368/full