Early experience with proton craniospinal irradiation in adult patients with leptomeningeal disease

Abstract Background Leptomeningeal disease (LMD) is a fatal complication of cancer linked to poor survival rates and limited treatment options. While photon involved-field radiotherapy is the standard of care for local palliation and symptom alleviation, it lacks durable disease control. Recent data...

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Bibliographic Details

Published in:	Radiation Oncology
Main Authors:	Felix Ehret, Ammy M. Yuan, Ariel E. Marciscano, Stephen Zieminski, Peggy A. Leland, Melin J. Khandekar, Kevin S. Oh, Helen A. Shih
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Leptomeningeal disease Leptomeningeal metastasis Brain metastasis Proton therapy Craniospinal irradiation CSI
Online Access:	https://doi.org/10.1186/s13014-025-02618-7