Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Abstract Background The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient, high doses of chemotherapeutic agent doxorubicin can be released from thermally-sensitive liposomes (ThermoDox®) using ultrasound-mediated hyp...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton, Constantin Coussios
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Doxorubicin Liposomes Liposomal FUS Focused ultrasound Hyperthermia
Online Access:	https://doi.org/10.1186/s12885-023-11228-z