Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant <i>Candida glabrata</i>

Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant <i>Candida glabrata</i> at 10 μg/mL (15.4 μM). The fungicidal effect was observed at 3 to 4 h after exposure to cells. Cytological and morphological...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Doralyn S. Dalisay, Evan W. Rogers, Tadeusz F. Molinski
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Subjects:
antifungal
Porifera
azole
long-chain base
sphingolipid
Online Access:https://www.mdpi.com/1660-3397/19/3/126

Internet

https://www.mdpi.com/1660-3397/19/3/126

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