Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes

BackgroundRecent clinical studies suggest protective effects of SGLT2 inhibitors on kidney disease outcome. Chronic hypoxia has a critical role in kidney disease development, thus we speculated that canagliflozin, an SGLT2 inhibitor, can improve kidney oxygenation.MethodsA single-arm study was condu...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Katsuhito Mori, Tsutomu Inoue, Yuri Machiba, Hideki Uedono, Shinya Nakatani, Masahiro Ishikawa, Satsuki Taniuchi, Yutaka Katayama, Akira Yamamoto, Naoki Kobayashi, Eito Kozawa, Taro Shimono, Yukio Miki, Hirokazu Okada, Masanori Emoto
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	SGLT2 inhibitor kidney oxygenation kidney disease type 2 diabetes GFR BOLD MRI
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1451671/full