Environmental manganese exposure accelerates metabolic dysfunction-associated steatotic liver disease by lipotoxic endoplasmic reticulum stress

Manganese (Mn) toxicity thresholds are established for healthy populations, yet individuals with metabolic disorders may exhibit heightened vulnerability. This study investigated whether environmentally relevant Mn concentrations exacerbate the progression from simple steatosis to steatohepatitis th...

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Bibliographic Details

Published in:	Environmental Chemistry and Ecotoxicology
Main Authors:	Longyi Liu, Youya Niu, Zhaolai Guo, Chengchen Wang, Hai Liu, Ji Yang, Peng Gao, Ping Xiang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-01-01
Subjects:	Manganese Hepatic steatosis Lipotoxicity Endoplasmic reticulum stress Metabolomics and lipidomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S259018262500181X