Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer

Abstract Background In triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the efficacy of immune checkpoint inhibitors. We have previously demonstrated that Hainanenin-1 (HN-1), a host defense peptide (HDP) identified from Hainan frog s...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Xiaoxi Li, Nan Su, Haining Yu, Xiaoyan Li, Shu-lan Sun
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Host defense peptide Immunogenic cell death STING Triple-negative breast cancer Anti-tumor immunity HN-1
Online Access:	https://doi.org/10.1186/s12964-024-01731-6