HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms

Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1’s role in chemoresistance and its potential as a therapeutic target in cancer. We explore...

Full description

Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Shruti Ghai, Rejina Shrestha, Kuo-Hui Su
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	heat shock factor 1 chemoresistance proteotoxic stress response autophagy apoptosis drug efflux
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1500880/full