Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS
Probing ssDNA binding to TAR-DNA-binding protein-43 (TDP-43) prion-like domain (PLD) through NMR shows key interactions for nucleic acid to drive liquid-liquid phase separation (LLPS) of intrinsically-disordered proteins.
| Published in: | Communications Biology |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Online Access: | https://doi.org/10.1038/s42003-022-04293-w |