A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

Human dihydroorotate dehydrogenase (DHODH), the enzyme that catalyzes the rate‐limiting step in de novo pyrimidine biosynthesis, is considered to be an attractive target for potential treatment of autoimmune disease and cancer. Here, we present a novel class of human DHODH inhibitors with high inhib...

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出版年:	FEBS Open Bio
主要な著者:	Ting Zeng, Zeping Zuo, Youfu Luo, Yinglan Zhao, Yamei Yu, Qiang Chen
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2019-08-01
主題:	crystal structure dihydroorotate dehydrogenase drug inhibitor pyrimidine biosynthesis
オンライン･アクセス:	https://doi.org/10.1002/2211-5463.12658