Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Abstract A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is typically hundreds to thousands of repea...

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Bibliographic Details
Published in:Acta Neuropathologica Communications
Main Authors: Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Format: Article
Language:English
Published: BMC 2020-09-01
Subjects:
Drosophila
Frontotemporal dementia
FTD
MND
Dipeptide-repeats
C9orf72
Online Access:http://link.springer.com/article/10.1186/s40478-020-01028-y

Internet

http://link.springer.com/article/10.1186/s40478-020-01028-y

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