The Protective Activity of Penehyclidine Hydrochloride against Renal Ischemia/Reperfusion-Mediated NLRP3 Inflammasome Activation is Induced by SIRT1

Background: The activation of alveolar macrophages (AMs) modulated via leucine-rich repeat (NLR) pyrin domain containing 3 (NLRP3) inflammasome activation is key to the progression of renal ischemia/reperfusion (rI/R)-mediated acute lung injury (ALI). Sirtuin-1 (SIRT1) can attenuate NLRP3 inflammaso...

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Bibliographic Details

Published in:	Journal of Investigative Surgery
Main Authors:	Zhaohui Liu, Yanli Meng, Qianjie Wei, Yu Miao, Lili Yu, Yuqing Li, Bing Zhang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-05-01
Subjects:	penehyclidine hydrochloride renal ischemia/reperfusion sirt1 alveolar macrophages acute lung injury
Online Access:	http://dx.doi.org/10.1080/08941939.2021.1995541