Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy

Abstract In vivo IR spectroscopy faces challenges due to poor sensitivity in reflection mode and low resolution at micrometer scale. To break this barrier, we report an oblique photothermal microscope (OPTM) to enable ultrasensitive IR spectroscopic imaging of live subjects at sub-micron resolution....

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Mingsheng Li, Sheng Xiao, Hongli Ni, Guangrui Ding, Yuhao Yuan, Carolyn Marar, Jerome Mertz, Ji-Xin Cheng
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41467-025-61332-w