A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of antimetabolite drugs and is essential for vir...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Molecules
المؤلفون الرئيسيون:	Inga R. Grin, Grigory V. Mechetin, Rustem D. Kasymov, Evgeniia A. Diatlova, Anna V. Yudkina, Sergei N. Shchelkunov, Irina P. Gileva, Alexandra A. Denisova, Grigoriy A. Stepanov, Ghermes G. Chilov, Dmitry O. Zharkov
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2021-11-01
الموضوعات:	DNA repair uracil–DNA glycosylase inhibitors virtual screening pyrimidines
الوصول للمادة أونلاين:	https://www.mdpi.com/1420-3049/26/21/6668