A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of antimetabolite drugs and is essential for vir...

Full description

Bibliographic Details
Published in:	Molecules
Main Authors:	Inga R. Grin, Grigory V. Mechetin, Rustem D. Kasymov, Evgeniia A. Diatlova, Anna V. Yudkina, Sergei N. Shchelkunov, Irina P. Gileva, Alexandra A. Denisova, Grigoriy A. Stepanov, Ghermes G. Chilov, Dmitry O. Zharkov
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	DNA repair uracil–DNA glycosylase inhibitors virtual screening pyrimidines
Online Access:	https://www.mdpi.com/1420-3049/26/21/6668

Similar Items

A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase
by: Wael Muselmani, et al.
Published: (2023-06-01)

Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases
by: Evgeniia A. Diatlova, et al.
Published: (2022-10-01)

Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening
by: Pansong Zhang, et al.
Published: (2024-09-01)

Mismatch uracil DNA glycosylase (Mug) is maintained in the Corynebacterium pseudotuberculosis genome and exhibits affinity for uracil but not other types of damage
by: Bruno Carvalho Resende, et al.
Published: (2025-04-01)

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues
by: Kyle R. Smith, et al.
Published: (2023-10-01)

Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity
by: Anna Ligasová, et al.
Published: (2021-10-01)

Colorimetric and electrochemical dual-signal detection of uracil-DNA glycosylase using functionalized pure DNA hydrogel on paper-based analytical devices
by: Wei Xue, et al.
Published: (2023-09-01)

One-pot, uracil-DNA-glycosylase-aided, and multi-indicator nanobiosensor detection platform for identifying Brucella melitensis from the Brucella spp
by: Xinggui Yang, et al.
Published: (2025-08-01)

HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines
by: Tobias S. Iveland, et al.
Published: (2020-04-01)

Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases
by: Paulina Prorok, et al.
Published: (2021-06-01)

Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA
by: Hala Ouzon-Shubeita, et al.
Published: (2025-05-01)

Real-time PCR method for detection of short DNA using a deoxyuridine probe and application for detection of fomivirsen
by: Naoki Harikai, et al.
Published: (2022-12-01)

Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L.
by: D. V. Petrova, et al.
Published: (2022-07-01)

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights
by: Jiawei Chen, et al.
Published: (2024-01-01)

Molecular Mechanisms Associated with Clustered Lesion-Induced Impairment of 8-oxoG Recognition by the Human Glycosylase OGG1
by: Tao Jiang, et al.
Published: (2021-10-01)

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation
by: Ryan Costello, et al.
Published: (2019-11-01)

DFT study on metal-mediated uracil base pair complexes
by: Ayhan Üngördü, et al.
Published: (2017-11-01)

DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition
by: Andreas Abentung, et al.
Published: (2025-08-01)

Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides
by: Anton V. Endutkin, et al.
Published: (2024-06-01)

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase
by: Diana Manapkyzy, et al.
Published: (2025-07-01)

Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process
by: Wang Lingyan, et al.
Published: (2022-05-01)

A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
by: Juan Miguel Baquero, et al.
Published: (2019-05-01)

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells
by: Yuqing Feng, et al.
Published: (2025-07-01)

The Human 8-oxoG DNA Glycosylase 1 (<i>OGG1</i>) <i>Ser</i>326<i>Cys</i> Polymorphism in Infertile Men
by: César Antonio González-Díaz, et al.
Published: (2024-10-01)

Single-nucleotide polymorphisms of uracil-processing genes affect the occurrence and the onset of recurrent depressive disorder
by: Piotr Czarny, et al.
Published: (2018-06-01)

Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia
by: Long-Xiu Yang, et al.
Published: (2016-01-01)

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents
by: Alisa Petriina Olkinuora, et al.
Published: (2022-10-01)

Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain
by: Jara Teresa Parrilla-Doblas, et al.
Published: (2017-04-01)

Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli
by: Caroline Zutterling, et al.
Published: (2018-12-01)

A thermophilic 8-oxoguanine DNA glycosylase from Thermococcus barophiluss Ch5 is a new member of AGOG DNA glycosylase family
by: Wang Lei, et al.
Published: (2022-06-01)

Quantification of DNase type I ends, DNase type II ends, and modified bases using fluorescently labeled ddUTP, terminal deoxynucleotidyl transferase, and formamidopyrimidine-DNA glycosylase
by: David S. Baskin, et al.
Published: (2010-07-01)

A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance
by: Ying-Qi Song, et al.
Published: (2023-05-01)

Evaluation of 8-Oxoguanine DNA Glycosylase-1(OGG1) Serum Levels in Patients with Type2 Diabetes Mellitus
by: Duaa Hussein Allawi Al-dulaimi
Published: (2024-12-01)

Reading and Misreading 8-oxoguanine, a Paradigmatic Ambiguous Nucleobase
by: Anna V. Yudkina, et al.
Published: (2019-05-01)

Synthesis of acetylenic mercpto uracil derivatives
by: Hala M. G. Alzahawy Farah Kh. H. ALjuboory
Published: (2013-12-01)

Viruses with U-DNA: New Avenues for Biotechnology
by: Kinga K. Nagy, et al.
Published: (2021-05-01)

Increasing quality, throughput and speed of sample preparation for strand-specific messenger RNA sequencing
by: Simon Haile, et al.
Published: (2017-07-01)

Establishment of UDG-LAMP-LFD Detection System for Aflatoxin-producing Bacteria
by: Hongyu AN, et al.
Published: (2025-06-01)

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
by: Erik C Hansen, et al.
Published: (2016-09-01)

Uracil Compounds As Inhibitors For Glutamate Oxaloactate Tansaminase (GOT) In Serum Of Some Leukemia Patients
by: Nadia Q. Haj
Published: (2015-09-01)