Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction

Abstract Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. Fear memory recall reactivates the consolidated fear memory trace across multiple brain regions, and several studies have suggested that these...

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Bibliographic Details

Published in:	Molecular Brain
Main Authors:	Yongmin Sung, Dae Hee Han, Junhyuk Kim, Pojeong Park, Bong-Kiun Kaang
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Remote fear memory extinction Recall-activated neurons N-methyl-d-aspartate receptors Clustered regularly interspaced short palindromic repeats (CRISPR)
Online Access:	https://doi.org/10.1186/s13041-025-01203-z