Regulation of expression of unintegrated and integrated HIV-1 DNA: keeping the wolves at bay

The unintegrated HIV-1 DNAs formed by reverse transcription in the early hours after infection are subject to profound transcriptional silencing. The repression of expression of foreign DNA, as an aspect of the innate immune system, serves to restrict the activity of many invading pathogens. Newly f...

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Bibliographic Details

Published in:	Frontiers in Virology
Main Author:	Stephen P. Goff
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	unintegrated DNA HIV-1 transcriptional silencing host factors histone modifications
Online Access:	https://www.frontiersin.org/articles/10.3389/fviro.2024.1481451/full