Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35

Abstract Background The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS). In this study, we investigated the mechanisms that link tigecycline susceptib...

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Bibliographic Details
Published in:Journal of Biomedical Science
Main Authors: Suyeon Park, Hyunkeun Kim, Kwan Soo Ko
Format: Article
Language:English
Published: BMC 2023-03-01
Subjects:
Klebsiella pneumoniae
Tigecycline
ompK35
ompR
Hypermucoviscosity
Online Access:https://doi.org/10.1186/s12929-023-00910-w

Internet

https://doi.org/10.1186/s12929-023-00910-w

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