Chromatin changes associated with neutrophil extracellular trap formation in whole blood reflect complex immune signaling

BackgroundNeutrophils are key players in innate immunity, forming neutrophil extracellular traps (NETs) to defend against infections. However, excess NET formation is implicated in inflammatory conditions such as sepsis and immunothrombosis. Studying NET formation in isolated neutrophils provides im...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Justin Cayford, Brandi Atteberry, Akanksha Singh-Taylor, Andrew Retter, Benjamin P. Berman, Theresa K. Kelly
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	NET formation NETosis chromatin PMA ATAC-seq innate immune system
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515430/full