Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology

Abstract Background The three-prime repair exonuclease 1, TREX1, degrades cytosolic DNA to prevent aberrant immune activation. Its inactivation results in DNA accumulation in the cytosol and induction of the cGAS-STING DNA sensing pathway, interferon signaling, and inflammation. Germline pathogenic...

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Bibliographic Details
Published in:Human Genomics
Main Authors: Marwa Shekfeh, Mariam M. Konaté, Julia Krushkal
Format: Article
Language:English
Published: BMC 2025-06-01
Subjects:
TREX1
Sequence variant
Copy number alteration
Innate immunity
Cancer
Autoimmune disease
Online Access:https://doi.org/10.1186/s40246-025-00785-y

Internet

https://doi.org/10.1186/s40246-025-00785-y

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