Nrf2 Signaling Pathway Mediates the Protective Effects of Daphnetin Against D-Galactose Induced-Premature Ovarian Failure

Oxidative damage can lead to severe ovarian dysfunctions and even premature ovarian failure. Nrf2, a significant transcription factor that regulates the oxidative stress response of cells, declines with age. Daphnetin, as a kind of natural Chinese herbal medicine, can activate Nrf2 and further promo...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Mengwen Zhang, Xiaowei Yu, Danjie Li, Ning Ma, Zhentong Wei, Xinxin Ci, Songling Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	premature ovarian failure Nrf2 NLRP3 Txnip daphentin
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.810524/full