BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.

The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines such as IL-1β, IL-18 or interferon β (IFN-β). N...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Dipanjan Dutta, Sujoy Dutta, Mohanan Valiya Veettil, Arunava Roy, Mairaj Ahmed Ansari, Jawed Iqbal, Leela Chikoti, Binod Kumar, Karen E Johnson, Bala Chandran
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-06-01
Online Access:	https://doi.org/10.1371/journal.ppat.1005030