Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up
L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were suggested (Aerosil 200, Aerosil R972, talc) t...
| Published in: | Acta Pharmaceutica |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-12-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2017-0033 |