Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor

IntroductionSolid cancers Myeloid cells are prevalent in solid cancers, but they frequently exhibit an anti-inflammatory pro-tumor phenotype that contribute to the immunosuppressive tumor microenvironment (TME), which hinders the effectiveness of cancer immunotherapies. Myeloid cells’ natural abilit...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Kayla Myers Chen, Daniel Grun, Brian Gautier, Shivaprasad Venkatesha, Michael Maddox, Ai-Hong Zhang, Peter Andersen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	macrophages chimeric antigen receptor (CAR) solid cancer PD-L1 PD-1 phagocytosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1380065/full