Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia

BackgroundCerebral ischemia triggers a cascade of detrimental events, leading to brain damage mainly due to the over-excitation of neurons. Currently, clinically applicable neuroprotective treatments to stop progressive neuronal death remain elusive. The GABAB receptor, crucial for neuronal inhibiti...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Mohammad Hleihil, Musadiq A. Bhat, Thomas Grampp, Dietmar Benke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	GABAB receptor interfering peptide cerebral ischemia neuron-specific targeting RVG blood brain barrier shuttles (BBBpS) middle cerebral artery occlusion (MCAO)
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1576884/full