Local Enrichment with Convergence of Enriched T-Cell Clones Are Hallmarks of Effective Peptide Vaccination against B16 Melanoma

Background: Some peptide anticancer vaccines elicit a strong T-cell memory response but fail to suppress tumor growth. To gain insight into tumor resistance, we compared two peptide vaccines, p20 and p30, against B16 melanoma, with both exhibiting good in vitro T-cell responses but different tumor s...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Anna Vyacheslavovna Izosimova, Alexandra Valerievna Shabalkina, Mikhail Yurevich Myshkin, Elizaveta Viktorovna Shurganova, Daria Sergeevna Myalik, Ekaterina Olegovna Ryzhichenko, Alina Faritovna Samitova, Ekaterina Vladimirovna Barsova, Irina Aleksandrovna Shagina, Olga Vladimirovna Britanova, Diana Vladimirovna Yuzhakova, George Vladimirovich Sharonov
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	peptide anticancer vaccine B16 melanoma TCR repertoire
Online Access:	https://www.mdpi.com/2076-393X/12/4/345