Comparative Prognostic Roles of β-Catenin Expression and Tumor–Stroma Ratio in Pancreatic Cancer: Neoadjuvant Chemotherapy vs. Upfront Surgery

The benefit of neoadjuvant chemotherapy (NAC) over upfront surgery (UFS) for resectable pancreatic ductal adenocarcinoma (PDAC) is increasingly recognized, yet prognostic biomarkers remain undefined. We evaluated tumor–stroma ratio (TSR), β-catenin (β-CTN) expression, and tumor budding (TB) in 84 re...

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Bibliographic Details

Published in:	Current Oncology
Main Authors:	Shu Oikawa, Hiroyuki Mitomi, So Murai, Akihiro Nakayama, Seiya Chiba, Shigetoshi Nishihara, Yu Ishii, Toshiko Yamochi, Hitoshi Yoshida
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	β-catenin pancreatic ductal adenocarcinoma digital image analysis immunohistochemistry neoadjuvant chemotherapy tumor budding
Online Access:	https://www.mdpi.com/1718-7729/32/10/578