Formulation and characterization of cholesterol-based nanoparticles of gabapentin protecting from retinal injury

IntroductionThis study aimed to prepare cholesterol and stearic acid-based solid lipid nanoparticles of gabapentin (GAB-SLNs) for protection against streptozotocin (STZ)-induced retinal injury in rats.MethodsWe prepared four preparations of GAB-SLNs using a hot high-shear homogenization ultrasonicat...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Hatem I. Mokhtar, Dina M. Khodeer, Sharifa Alzahrani, Mona Qushawy, Reem Alshaman, Nehal M. Elsherbiny, Esam Sayed Ahmed, Esam Ghanem Abu El Wafa, Mohamed K. El-Kherbetawy, Ahmed R. Gardouh, Sawsan A. Zaitone
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	gabapentin IL6/JAK2/STAT3 signaling retinal injury rat solid lipid nanoparticles
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2024.1449380/full