Important role of the SDF-1/CXCR4 axis in the homing of systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) to ovaries in rats with chemotherapy-induced premature ovarian insufficiency (POI)

Abstract Background Chemotherapy can induce premature ovarian insufficiency (POI). POI causes multiple sequelae and is currently incurable. As shown in our previous studies, systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) home to ovaries with chemotherapy-induced POI...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Stem Cell Research & Therapy
المؤلفون الرئيسيون:	Li Ling, Jiying Hou, Dandan Liu, Dongyuan Tang, Yanqin Zhang, Qianru Zeng, Heng Pan, Ling Fan
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2022-02-01
الموضوعات:	Premature ovarian insufficiency (POI) Human amnion-derived mesenchymal stem cells (hAD-MSCs) Transplantation Stem cell homing Stromal cell-derived factor-1 (SDF-1) CXC chemokine receptor 4 (CXCR4)
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13287-022-02759-6