(−)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study

Upon acylation of the proteasome by the β-lactone inhibitor salinosporamide A (SalA), tetrahydrofuran formation occurs by intramolecular alkylation of the incipient alkoxide onto the choroethyl sidechain and irreversibly blocks the active site. Our previously described synthetic approach to...

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書誌詳細

出版年:	Marine Drugs
主要な著者:	Michael Groll, Henry Nguyen, Sreekumar Vellalath, Daniel Romo
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2018-07-01
主題:	beta-lactone anticancer natural products yeast 20S proteasome aldol-lactonization
オンライン･アクセス:	http://www.mdpi.com/1660-3397/16/7/240