Human induced neural progenitor cells generated from three-dimensional aggregate-based culture significantly improve post-stroke recovery in tMCAO mice

Abstract Background Despite the high prevalence of cerebral ischemic stroke, effective clinical treatments remain limited. With the development of regenerative medicine, induced neural progenitor cells (iNPCs) demonstrate ideal potential and good availability for autologous transplantation therapy....

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Zeqin Fu, Yue Hu, Yuxia Wang, Zhijie Liu, Mengyuan Li, Yanqiu Guo, Zhiwei Hu, Xingqiang Lai, Junyuan Hu, Yan Liao, Cheguo Cai
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	Induced neural progenitor cells 3D aggregates Stem cell transplantation Chronic ischemic stroke Post-stroke recovery
Online Access:	https://doi.org/10.1186/s13287-025-04433-z