Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies

Electroporation (EP) stands out as a promising non-viral plasmid delivery strategy, although achieving optimal transfection efficiency in vivo remains a challenge. A noteworthy advancement in the field of in vivo EP is the application of hyaluronidase, an enzyme with the capacity to degrade hyaluron...

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发表在:	Pharmaceutics
Main Authors:	Debnath Maji, Verónica Miguela, Andrew D. Cameron, Delcora A. Campbell, Linda Sasset, Xin Yao, Andy T. Thompson, Carleigh Sussman, David Yang, Robert Miller, Marek M. Drozdz, Rachel A. Liberatore
格式:	文件
语言:	英语
出版:	MDPI AG 2024-04-01
主题:	hyaluronidase plasmid DNA electroporation bioimpedance extracellular matrix transfection
在线阅读:	https://www.mdpi.com/1999-4923/16/4/547