Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives

The coupling of 2-bromo-3-benzoyloxycyclobutanone with purine under basic conditions produces two regioisomers consisting of the <i>N-7</i> and <i>N-9</i> alkylated products in equal amounts in their racemic forms. The distribution of the isomers is consistent with the charge...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Noha Hasaneen, Abdelaziz Ebead, Muhammad Murtaza Hassan, Hanan Afifi, Howard Hunter, Edward Lee-Ruff, Nadia S. El-Gohary, Azza R. Maarouf, Ali A. El-Emam
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Subjects:	nucleoside analogs cyclobutanes purine uracil thymine
Online Access:	https://www.mdpi.com/1420-3049/24/18/3235