Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players

Deficits in cognitive flexibility have been characterized in affective, anxiety, and neurodegenerative disorders. This paper reviews data, mainly from studies on animal models, that support the existence of a cortical–striatal brain circuit modulated by dopamine (DA), playing a major role in cogniti...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Emanuele Claudio Latagliata, Cristina Orsini, Simona Cabib, Francesca Biagioni, Francesco Fornai, Stefano Puglisi-Allegra
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Subjects:	medial prefrontal cortex nucleus accumbens dopamine extinction goal-directed therapy
Online Access:	https://www.mdpi.com/2227-9059/11/12/3189