IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.

Chronic Obstructive Pulmonary Disease (COPD) is characterized by airspace enlargement and peribronchial lymphoid follicles; however, the immunological mechanisms leading to these pathologic changes remain undefined. Here we show that cigarette smoke is a selective adjuvant that augments in vitro and...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Kong Chen, Derek A Pociask, Jeremy P McAleer, Yvonne R Chan, John F Alcorn, James L Kreindler, Matthew R Keyser, Steven D Shapiro, A McGarry Houghton, Jay K Kolls, Mingquan Zheng
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21647421/?tool=EBI