Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors

Phosphodiesterases (PDE) are group of enzymes which catalyze the hydrolysis of cAMP and cGMP. Since these cyclic phosphate moieties worked as intracellular second messengers in numerous physiological processes, their inhibition can affect normal physiology of living system. NSAIDs are among the freq...

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Bibliographic Details

Published in:	Brazilian Journal of Pharmaceutical Sciences
Main Authors:	Shumaila Tasneem, Muhammad Saleem, Sheikh Arshad Saeed
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2020-03-01
Subjects:	Non-steroidal antiinflammatory drugs Cyclooxygenase Phosphodiesterase Inflammation cAMP
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100531&tlng=en