Identification of Influenza PA_N Endonuclease Inhibitors via 3D-QSAR Modeling and Docking-Based Virtual Screening

Structural and biochemical studies elucidate that PA_N may contribute to the host protein shutdown observed during influenza A infection. Thus, inhibition of the endonuclease activity of viral RdRP is an attractive approach for novel antiviral therapy. In order to envisage stru...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Chao Zhang, Junjie Xiang, Qian Xie, Jing Zhao, Hong Zhang, Erfang Huang, Pangchui Shaw, Xiaoping Liu, Chun Hu
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	3D-QSAR pharmacophore model PA<sub>N</sub> endonuclease PA<sub>N</sub> endonuclease inhibitors raltegravir
Online Access:	https://www.mdpi.com/1420-3049/26/23/7129